Kath Soucie was the second voice actor to play the part of Janine Melnitz in the cartoon series The Real Ghostbusters. Kath Soucie said she was a great fan of the film Ghostbusters, but had never seen the animated series before being cast for the part. Kath Soucie primarily makes her living doing voice acting work in cartoons.
Kath Soucie is noted as playing the parts of the twins Phil and Lil in the animated series Rugrats. She played the voice of Bubbles the Powerpuff Girl in What-a-Cartoon. She also plays the part of Cubert Farnsworth, the clone, in Futurama.